Article

Extracellular matrix sulfation in the tumor microenvironment stimulates cancer stemness and invasiveness

2023-10-20

Abstract excerpt

Tumor extracellular matrices (ECM) exhibit aberrant changes in composition and mechanics compared to normal tissues. Proteoglycans (PG) are vital regulators of cellular signaling in the ECM with ability to modulate receptor tyrosine kinase (RTK) activation via their sulfated glycosaminoglycan (sGAG) side chains. However, their role on tumor cell behavior is controversial. Here, we demonstrate that PGs are heavily...

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Literature Corpus work: 8f1030d3-beb0-5dcf-89e9-1f1041de2dec
DOI: 10.1101/2023.10.17.562578

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