Article

Hypoglycosylation lowers the mechanical activation threshold of Piezo1 and enhances cortical neuronal mechanotransduction: implications for PMM2-CDG

2026-08-07

Abstract excerpt

Piezo1 is a mechanically activated cation channel whose N-linked glycans support protein maturation and plasma membrane trafficking, but their contribution to mechanical gating is unknown. We asked whether hypoglycosylation alters Piezo1 mechanosensitivity and cortical neuronal mechanotransduction, with potential relevance to neurological manifestations of congenital disorders of glycosylation (CDG). Human Piezo1...

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Literature Corpus work: ac1395d3-f5b5-5cba-83c0-6a942fea012d
DOI: 10.64898/2026.08.03.742511

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Hypoglycosylation lowers the mechanical activation threshold of Piezo1 and enhances cortical neuronal mechanotransduction: implications for PMM2-CDGDOI 10.64898/2026.08.03.742511Read

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