Article

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

2020-12-01

Abstract excerpt

Mechanosensitive channels are integral membrane proteins that sense mechanical stimuli. Like all membrane proteins, they pass through biosynthetic quality control in the endoplasmic reticulum and Golgi that results in them reaching their destination at the plasma membrane. Here we show that N-linked glycosylation of two highly conserved asparagine residues in the ‘cap’ region of mechanosensitive Piezo1 channels ar...

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Literature Corpus work: b4862df8-e9bc-53f9-a36f-baee3ca419fb
DOI: 10.1101/2020.11.30.404962

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