Piezo2 tension sensitivity and its modulation by alternative splicing

Abstract excerpt

Piezo2 is a force-gated ion channel that functions as a sensor of mechanical touch, proprioception, lung inflation, and gut transit. Human Piezo2 contains seven domains that are alternatively spliced in a tissue-specific fashion resulting in the expression of at least 22 distinct variants. Despite the relevance of Piezo2 in human physiology, its sensitivity to membrane tension, and how this fundamental biophysical...

Topics

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• Erythrocyte Function and Pathophysiology
• Gene Silencing
• Gene Transfer Techniques
• HEK293 Cells
• Ion channel regulation and function
• Ion Channels
• Lipid Membrane Structure and Behavior
• Mechanotransduction, Cellular

Identifiers and source

Literature Corpus work

479c42ea-2355-5475-85e6-c73da6b0c2fe

DOI

10.64898/2026.02.16.706133