Article
Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations.
Communications biology - 6 Sept 2021
Li Jinyuan Vero, Ng Chai-Ann, Cheng Delfine, Zhou Zijing, Yao Mingxi, Guo Yang, Yu Ze-Yan, Ramaswamy Yogambha, Ju Lining Arnold, Kuchel Philip W, Feneley Michael P, Fatkin Diane, Cox Charles D
Abstract excerpt
Mechanosensitive channels are integral membrane proteins that sense mechanical stimuli. Like most plasma membrane ion channel proteins they must pass through biosynthetic quality control in the endoplasmic reticulum that results in them reaching their destination at the plasma membrane. Here we show that N-linked glycosylation of two highly conserved asparagine residues in the 'cap' region of mechanosensitive...
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