Article

A Propeller with a Flexible Twist: The Roles of Intrinsically Disordered Regions in PIEZO Gating and PIEZO-Associated Channelopathies

2026-06-02

Abstract excerpt

<h4>Background: </h4> Mechanosensitive ion channels PIEZO1 and PIEZO2 are key mediators of mechanotransduction, which converts physical forces into cellular signals involved in proprioception, touch, vascular function, and other physiological processes. Mutations in human PIEZO proteins are linked to various diseases, such as hereditary xerocytosis, lymphatic dysplasia, and proprioceptive dysfunction. However, the...

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Literature Corpus work: 04f28122-91de-5e93-8c0b-057734b426ed
DOI: 10.20944/preprints202606.0097.v1

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