Back to search

Article

The C3-C3aR axis modulates trained immunity in alveolar macrophages

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> Complement protein C3 is crucial for immune responses in mucosal sites such as the lung, where it aids in microbe elimination and enhances inflammation. While trained immunity – enhanced secondary responses of innate immune cells after prior exposure – is well-studied, the role of the complement system in trained immune responses remains unclear. We investigated the role of C3 in trained immunit...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ac11532c-f8a1-5695-af89-f9f727555874
DOI
10.1101/2024.11.01.621042
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The C3-C3aR axis modulates trained immunity in alveolar macrophagesDOI 10.1101/2024.11.01.621042
Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages.Semantic proximity
The versatile functions of complement C3‐derived ligandsSemantic proximity
The “ins and outs” of complement‐driven immune responsesSemantic proximity
A predominately pulmonary activation of complement in a mouse model of severe COVID-19Semantic proximity
C3d of complement as a molecular adjuvant: Bridging innate and acquired immunitySemantic proximity
Kinetics of local C3 production orchestrates neutrophil recruitment in lung injurySemantic proximity
Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell DeathSemantic proximity
Complement‐mediated immune mechanisms in allergySemantic proximity
New insights into the role of the complement pathway in allergy and asthma.Semantic proximity
C1q reprograms innate immune memory.Semantic proximity
A complex role for complement in allergic asthma.Semantic proximity
C1QA is an invariant biomarker for tissue macrophagesSemantic proximity
Select a neighboring publication to make it the new centre.