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Article

Complement system component 3 deficiency modulates the phenotypic profile of murine macrophages.

Cellular immunology - 1 Jan 2024

Francisco da Silva Tiago, Akemi Amamura Thaís, Cordeiro Valadão Iuri, Carvalho Carneiro Milena, Morais Freitas Vanessa, Paula Lepique Ana, Isaac Lourdes

Abstract excerpt

The Complement System is composed of more than 40 proteins that act in innate and adaptive immunity. C3 is the most abundant one and C3-deficient patients are more susceptible to recurrent and severe infections. Several studies have demonstrated the importance of C3 in controlling infections. However, its role in leukocyte biology is still poorly understood. This study aimed to evaluate several cellular...

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Identifiers

PMID: 39503081
DOI: 10.1016/j.cellimm.2024.104886

Genes

C3

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