Article

Kinetics of local C3 production orchestrates neutrophil recruitment in lung injury

2026-02-18

Abstract excerpt

<h4>ABSTRACT</h4> Complement component 3 (C3) is crucial for host defense against bacteria. While the liver is the primary source of circulating C3, local C3 production at barrier surfaces such as the lung is key in early responses. Yet, how local complement-mediated responses are initiated at mucosal barriers is unknown. This study investigates the kinetics and necessity of lung-derived C3 during the initial hou...

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Literature Corpus work: 3e894064-29b5-59cb-83cc-5d2d664f4450
DOI: 10.64898/2026.02.17.706326

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