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Cell-intrinsic complement C3 suppresses IFN-β production in macrophages

2026-08-31

Abstract excerpt

The cell-intrinsic complement system has emerged as an important orchestrator of a variety of cell-physiological processes, with complement components interacting with intracellular effector systems to regulate cellular responses to pathogens or noxious stimuli. For instance, intracellular C5 signaling through a mitochondrial C5a receptor (C5aR1) controls IL-1β production in human monocytes and macrophages. Here,...

Identifiers and source

Literature Corpus work
918dc669-0388-592b-95c3-dfeed25e844e
DOI
10.64898/2026.08.26.746684
Open publication

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Cell-intrinsic complement C3 suppresses IFN-β production in macrophagesDOI 10.64898/2026.08.26.746684
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