Article

A predominately pulmonary activation of complement in a mouse model of severe COVID-19

2024-06-03

Abstract excerpt

Evidence from in vitro studies and observational human disease data suggest the complement system plays a significant role in SARS-CoV-2 pathogenesis, although how complement dysregulation develops in patients with severe COVID-19 is unknown. Here, using a mouse-adapted SARS-CoV-2 virus (SARS2-N501Y MA30 ) and a mouse model of severe COVID-19, we identify significant serologic and pulmonary complement activation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 42fafe51-3ddd-5349-92c7-9f340a0ccbdc
DOI: 10.1101/2024.05.31.596892

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A predominately pulmonary activation of complement in a mouse model of severe COVID-19DOI 10.1101/2024.05.31.596892Read

Complement is primarily activated in the lung in a mouse model of severe COVID-19Semantic proximity Read

Emerging role of complement in COVID-19 and other respiratory virus diseasesSemantic proximity Read

Complement control for COVID-19Semantic proximity Read

Rationale for targeting complement in COVID‐19Semantic proximity Read

Activation of classical and alternative complement pathways in the pathogenesis of lung injury in COVID-19Semantic proximity Read

A complement atlas identifies interleukin-6–dependent alternative pathway dysregulation as a key druggable feature of COVID-19Semantic proximity Read

Complement cascade in severe forms of COVID‐19: Recent advances in therapySemantic proximity Read

The Complement System: A Bridge Between Innate and Adaptive Immunity and an Influencer of Eosinophilic Inflammation in Respiratory DiseasesSemantic proximity Read

Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID‐19Semantic proximity Read

Complement and coagulation: key triggers of COVID-19–induced multiorgan pathologySemantic proximity Read

Severe COVID-19 is associated with hyperactivation of the alternative complement pathwaySemantic proximity Read

The complement system: A key player in the host response to infectionsSemantic proximity Read