Article

Adjuvant and immunomodulatory potential of <i>in vivo</i> Natural Killer T (NKT) activation by NKTT320

2021-04-28

Abstract excerpt

Invariant natural killer T-lymphocytes (iNKT) are unique immunomodulatory innate T-cells with an invariant TCRα recognizing glycolipids presented on MHC class-I-like CD1d molecules. Activated iNKT rapidly secrete pro-and anti-inflammatory cytokines, potentiate innate and adaptive immunity, and modulate inflammation. Here, we report the effects of in vivo iNKT activation by a novel humanized monoclonal antibody, N...

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Literature Corpus work: ac1016ce-7ead-5f28-9f98-09e4f78dd30d
DOI: 10.1101/2021.04.27.441000

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