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Article

IL-33 drives polyfunctionality and antitumor activity of a unique ST2+ NK cell population

2023-02-15

Abstract excerpt

Natural Killer (NK) cell subsets differ to ensure complementary and crucial roles in tumor immunosurveillance. Their biology is critically regulated by cytokines. Here, we show that IL-33 synergizes with IL-12 to strongly activate a subset of CD56 dim NK cells acquiring ST2 expression. Transcriptomic and biological analysis of human ST2 + CD56 dim NK cells revealed a distinct intermediate differentiation state...

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Identifiers and source

Literature Corpus work
3323a469-9105-5e7a-8996-606b3958d88e
DOI
10.1101/2023.02.14.528486
Open publication

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IL-33 drives polyfunctionality and antitumor activity of a unique ST2+ NK cell populationDOI 10.1101/2023.02.14.528486
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