Article
Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.
PLoS neglected tropical diseases - 1 Jun 2017
Mwenechanya Roy, Kovářová Julie, Dickens Nicholas J, Mudaliar Manikhandan, Herzyk Pawel, Vincent Isabel M, Weidt Stefan K, Burgess Karl E, Burchmore Richard J S, Pountain Andrew W, Smith Terry K, Creek Darren J, Kim Dong-Hyun, Lepesheva Galina I, Barrett Michael P
Abstract excerpt
Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is therefore of great importance. Here we select amphotericin B-resistant Leishmania mexicana parasites with relative ease....
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