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Article

Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania.

The EMBO journal - 21 Feb 2007

Zhang Kai, Pompey Justine M, Hsu Fong-Fu, Key Phillip, Bandhuvula Padmavathi, Saba Julie D, Turk John, Beverley Stephen M

Abstract excerpt

In most eukaryotes, sphingolipids (SLs) are critical membrane components and signaling molecules. However, mutants of the trypanosomatid protozoan Leishmania lacking serine palmitoyltransferase (spt2-) and SLs grow well, although they are defective in stationary phase differentiation and virulence. Similar phenotypes were observed in sphingolipid (SL) mutant lacking the degradatory enzyme sphingosine 1-phosphate...

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Identifiers

PMID: 17290222
DOI: 10.1038/sj.emboj.7601565
PMCID: PMC1852826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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