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Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in Leishmania major.

mSphere - 1 Jul 2020

Ning Yu, Frankfater Cheryl, Hsu Fong-Fu, Soares Rodrigo P, Cardoso Camila A, Nogueira Paula M, Lander Noelia Marina, Docampo Roberto, Zhang Kai

Abstract excerpt

Lathosterol oxidase (LSO) catalyzes the formation of the C-5-C-6 double bond in the synthesis of various types of sterols in mammals, fungi, plants, and protozoa. In Leishmania parasites, mutations in LSO or other sterol biosynthetic genes are associated with amphotericin B resistance. To investigate the biological roles of sterol C-5-C-6 desaturation, we generated an LSO-null mutant line (lso- ) in Leishmania...

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Identifiers

PMID: 32611698
DOI: 10.1128/mSphere.00380-20
PMCID: PMC7333571

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