Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteolysis of TAM receptors in autoimmune diseases and cancer: what does it say to us?

5 Mar 2025

Abstract excerpt

Proteolytic processing of Receptor Tyrosine Kinases (RTKs) leads to the release of ectodomains in the extracellular space. These soluble ectodomains often retain the ligand binding activity and dampen canonical pathways by acting as decoy receptors. On the other hand, shedding the ectodomains may initiate new molecular events and diversification of signalling. Members of the TAM (TYRO3, AXL, MER) family of RTKs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Erythrocyte Function and Pathophysiology
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40044635
DOI: 10.1038/s41419-025-07480-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteolysis of TAM receptors in autoimmune diseases and cancer: what does it say to us?PMID 40044635Read ↗

The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An OverviewSemantic proximity Read ↗

TAM Receptor Signaling in Immune HomeostasisSemantic proximity Read ↗

TAM receptors in apoptotic cell clearance, autoimmunity, and cancerSemantic proximity Read ↗

The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer TherapySemantic proximity Read ↗

New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid ArthritisSemantic proximity Read ↗

TAM receptors in phagocytosis: Beyond the mere internalization of particlesSemantic proximity Read ↗

MERTK Inhibition as a Targeted Novel Cancer TherapySemantic proximity Read ↗

TAM kinases as regulators of cell death.Semantic proximity Read ↗

Cysteine cathepsins: From diagnosis to targeted therapy of cancerSemantic proximity Read ↗

Hallmarks of pancreatic cancer: spotlight on TAM receptors.Semantic proximity Read ↗

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosisSemantic proximity Read ↗

Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.