Back to search

Article

A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated Oligonucleotides

2022-06-17

Abstract excerpt

<h4>ABSTRACT</h4> We have developed a non-cationic transfection vector in the form of a bottlebrush polymer-antisense oligonucleotide (ASO) conjugate. Termed pacDNA (polymer-assisted compaction of DNA), these agents show improved biopharmaceutical characteristics and antisense potency in vivo while suppressing non-antisense side effects. Nonetheless, there still lacks a mechanistic understanding regarding the cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
abaebcfd-ea1f-5b01-934a-797ecad626c1
DOI
10.1101/2022.06.15.496353
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated OligonucleotidesDOI 10.1101/2022.06.15.496353
Bottlebrush Polymer Conjugates for Enhanced Antisense Oligonucleotide Therapy in Myotonic Dystrophy Type 1Semantic proximity
Theranostic DNA nanostructure based on phenotype-specific activation of antisense oligonucleotides.Semantic proximity
SCAD Delivery Platform: A Novel Approach for Efficient CNS and Extrahepatic Oligonucleotide TherapeuticsSemantic proximity
Antisense Oligonucleotides: Technological Advances, Clinical Progress, and Expanding Therapeutic FrontiersSemantic proximity
A comprehensive update of siRNA delivery design strategies for targeted and effective gene silencing in gene therapy and other applicationsSemantic proximity
Programmable Aptamer-Embedded Circular RNAs for Targeted Antigen-Presenting Cells ImmunotherapySemantic proximity
Antisense Oligonucleotides: Treatment Strategies and Cellular InternalizationSemantic proximity
The Versatile Applications of Antisense Oligonucleotides in Modern MedicineSemantic proximity
Transfection Technologies for Next-Generation TherapiesSemantic proximity
Polymeric Carriers for Delivery of RNA Cancer TherapeuticsSemantic proximity
Non-viral nucleic acid containing nanoparticles as cancer therapeuticsSemantic proximity
SCAD: A Modular Platform for Efficient Delivery of Duplex RNA to the CNS and BeyondSemantic proximity
Select a neighboring publication to make it the new centre.