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Article

SCAD: A Modular Platform for Efficient Delivery of Duplex RNA to the CNS and Beyond

2025-03-26

Abstract excerpt

<title>Abstract</title> <p>Oligonucleotide therapeutics, including antisense oligonucleotides (ASOs) and duplex RNAs like siRNA, saRNA and miRNA, hold immense potential for treating genetic and acquired diseases by modulating gene expression in a target-specific manner. However, effective delivery to extrahepatic tissues, particularly the central nervous system (CNS), remains a significant challenge. While GalNAc...

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Literature Corpus work
a08aed49-958a-5fdc-a5d2-43c5caa738a7
DOI
10.21203/rs.3.rs-5904176/v1
Open publication

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SCAD: A Modular Platform for Efficient Delivery of Duplex RNA to the CNS and BeyondDOI 10.21203/rs.3.rs-5904176/v1
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