Article

Temperature-Dependent Replication and Sensitivity to Innate Immunity of Human Coronavirus HKU1

2026-05-12

Abstract excerpt

The human coronavirus HKU1, causing common colds and occasionally severe illness, remains largely uncharacterized because it has not been successfully grown on immortalized cells. Here, we identified Caco2 cells overexpressing TMPRSS2, the HKU1 receptor, as being highly permissive to infection. HKU1 replicated efficiently, formed syncytia and released infectious progeny in these cells at 33°C, the temperature of t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab781053-ebe1-51ea-bb58-d12834e60dd4
DOI: 10.64898/2026.05.07.723210

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Temperature-Dependent Replication and Sensitivity to Innate Immunity of Human Coronavirus HKU1DOI 10.64898/2026.05.07.723210Read

Early transcriptional responses of human nasal epithelial cells to infection with Influenza A and SARS-CoV-2 virus differ and are influenced by physiological temperatureSemantic proximity Read

Disparate temperature-dependent virus – host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epitheliumSemantic proximity Read

Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epitheliumSemantic proximity Read

Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearanceSemantic proximity Read

Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of the induction of IFN-mediated innate immune defencesSemantic proximity Read

Recapitulating infection, thermal sensitivity and antiviral treatment of seasonal coronaviruses in human airway organoidsSemantic proximity Read

Human Norovirus Replication in Temperature-Optimized MDCK Cells by Forkhead Box O1 Inhibition.Semantic proximity Read

The cold-inducible RNA-binding protein RBM3 stabilises viral mRNA at cooler temperatures representative of the upper respiratory tractSemantic proximity Read

Human airway organoids model SARS-CoV-2 high infectiousness and evasion of interferon responseSemantic proximity Read

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airwaysSemantic proximity Read

Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperatureSemantic proximity Read

Age- and Virus-Specific Signatures of <i>In Vitro</i> Reconstituted Human Airway Epithelia in the Presence and Absence of Respiratory Viral InfectionsSemantic proximity Read