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Article

Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperature

11 Jul 2016

Abstract excerpt

Most strains of rhinovirus (RV), the common cold virus, replicate better at cool temperatures found in the nasal cavity (33-35 °C) than at lung temperature (37 °C). Recent studies found that although 37 °C temperature suppressed RV growth largely by engaging the type 1 IFN response in infected epithelial cells, a significant temperature dependence to viral replication remained in cells devoid of IFN induction or...

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PMID: 27402752
DOI: 10.1073/pnas.1601942113

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