Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearance

17 May 2024

Abstract excerpt

All respiratory viruses establish primary infections in the nasal epithelium, where efficient innate immune induction may prevent dissemination to the lower airway and thus minimize pathogenesis. Human coronaviruses (HCoVs) cause a range of pathologies, but the host and viral determinants of disease during common cold versus lethal HCoV infections are poorly understood. We model the initial site of infection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Respiratory viral infections research
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38758698
DOI: 10.1073/pnas.2402540121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon signaling in the nasal epithelium distinguishes among lethal and common cold coronaviruses and mediates viral clearancePMID 38758698Read ↗

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity Read ↗

Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2Semantic proximity Read ↗

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesSemantic proximity Read ↗

Human nasal and lung tissues infected <i>ex vivo</i> with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tractSemantic proximity Read ↗

Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicatingSemantic proximity Read ↗

Comparison of SARS-CoV-2 variants of concern in primary human nasal cultures demonstrates Delta as most cytopathic and Omicron as fastest replicatingSemantic proximity Read ↗

Tonic interferons defend against respiratory viruses in primary human lung organoid-derived air-liquid interface culturesSemantic proximity Read ↗

Early transcriptional responses of human nasal epithelial cells to infection with Influenza A and SARS-CoV-2 virus differ and are influenced by physiological temperatureSemantic proximity Read ↗

Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory TractSemantic proximity Read ↗

SARS-CoV-2 Omicron Induces Enhanced Mucosal Interferon Response Compared to other Variants of Concern, Associated with Restricted Replication in Human Lung TissuesSemantic proximity Read ↗

Molecular pathology of emerging coronavirus infectionsSemantic proximity Read ↗

Two interferon-independent double-stranded RNA-induced host defense strategies suppress the common cold virus at warm temperatureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.