Article

Integrated Single-Dose Kinome Profiling Data is Predictive of Cancer Cell Line Sensitivity to Kinase Inhibitors

2022-12-10

Abstract excerpt

Protein kinase activity forms the backbone of cellular information transfer, acting both individually and as part of a broader network, the kinome. Correspondingly, their central role in signaling implicates kinome dysfunction as a common driver of cancer, where numerous kinases have been identified as having a causal or modulating role in cancer development and progression. Driven by their importance, the develop...

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Literature Corpus work: f4733d70-da7c-5f1f-b8f3-7e282e46c819
DOI: 10.1101/2022.12.06.519165

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