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Article

Exploiting polypharmacology for drug target deconvolution.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2014

Gujral Taranjit Singh, Peshkin Leonid, Kirschner Marc W

Abstract excerpt

Polypharmacology (action of drugs against multiple targets) represents a tempting avenue for new drug development; unfortunately, methods capable of exploiting the known polypharmacology of drugs for target deconvolution are lacking. Here, we present an ensemble approach using elastic net regularization combined with mRNA expression profiling and previously characterized data on a large set of kinase inhibitors...

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Identifiers

PMID: 24707051
DOI: 10.1073/pnas.1403080111
PMCID: PMC3977247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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