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Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy

20 Mar 2024

Abstract excerpt

A large-scale multimodal atlas that includes major kidney regions is lacking. Here, we employed simultaneous high-throughput single-cell ATAC/RNA sequencing (SHARE-seq) and spatially resolved metabolomics to profile 54 human samples from distinct kidney anatomical regions. We generated transcriptomes of 446,267 cells and chromatin accessibility profiles of 401,875 cells and developed a package to analyze 408,218...

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PMID: 38513647
DOI: 10.1016/j.cmet.2024.02.015

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