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Bioenergetics: the evolutionary basis of progressive kidney disease

30 Mar 2023

Abstract excerpt

Chronic kidney disease (CKD) affects >10% of the world population, with increasing prevalence in middle age. The risk for CKD is dependent on the number of functioning nephrons through the life cycle, and 50% of nephrons are lost through normal aging, revealing their vulnerability to internal and external stressors. Factors responsible for CKD remain poorly understood, with limited availability of biomarkers or...

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PMID: 36996412
DOI: 10.1152/physrev.00029.2022

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