Article

Influence of <i>cis</i> -regulatory elements on expression divergence in human segmental duplications

2025-10-05

Abstract excerpt

<h4>ABSTRACT</h4> Human-specific segmental duplications (HSDs) contain millions of base pairs of sequence unique to the human genome, including genes that shape neurodevelopment. Despite their young age (<6 million years), HSD genes exhibit widespread regulatory divergence, with paralog-specific expression patterns documented across a variety of tissues and cell types. Using long-read expression and epigenomic da...

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Literature Corpus work: 851dda86-d06e-5da6-b46d-c2fa53ff5cda
DOI: 10.1101/2025.10.03.680410

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