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Joint Segmental Duplication Co-option Drives Human-specific Transcriptional Readthrough and Expression Fine-tuning of NPEPPS - TBC1D3

2026-01-15

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Segmental duplication (SD) is a major driver of functional changes in evolution and disease. Many genes embedded within SDs, such as NPEPPS and TBC1D3 , display substantial copy number variation (CNV) across individuals. Yet, the precise identification of the functional copies and their transcriptional outputs remains largely unstudied. Focusing on NPEPPS and TBC1D3 , we illustrate human-specific expression fi...

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Literature Corpus work: 90ddbc98-18af-5376-9de8-33330b9a9c9b
DOI: 10.64898/2026.01.14.699191

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Joint Segmental Duplication Co-option Drives Human-specific Transcriptional Readthrough and Expression Fine-tuning of <i>NPEPPS</i> - <i>TBC1D3</i>

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