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Single-Cell Multiomics Reveals Regulatory Mechanisms of CAR T Cell Persistence and Dysfunction in Multiple Myeloma

2025-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Understanding the mechanisms that drive chimeric antigen receptor (CAR) T cell function and persistence in multiple myeloma (MM) remains a critical challenge for improving therapeutic outcomes. In this study, we applied single-cell multiomics and gene regulatory network (GRN) analysis to characterize the transcriptional dynamics and clonal evolution of BCMA-targeted CAR T cells in longitudinally...

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Literature Corpus work
ab480577-cab8-5b4c-a03b-703900dfa2e6
DOI
10.1101/2025.04.01.646378
Open publication

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Single-Cell Multiomics Reveals Regulatory Mechanisms of CAR T Cell Persistence and Dysfunction in Multiple MyelomaDOI 10.1101/2025.04.01.646378
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