Article

Longitudinal multi-omic profiling uncovers immune escape and predictors of response in multiple myeloma

2025-05-31

Abstract excerpt

Multiple myeloma (MM) is an incurable malignancy of clonally expanded plasma cells shaped by complex interactions with the immune microenvironment. To investigate immune factors driving treatment response and resistance, we conducted multi-omics profiling including CD138 neg single-cell RNA sequencing of 243 bone marrow samples from 102 patients (631,226 cells) and CD138 pos bulk RNA and whole-genome sequencing...

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Literature Corpus work: 2329a8fa-55b6-5d6c-a97d-beed3af73dac
DOI: 10.1101/2025.05.27.656392

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