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Plasma cell identity escape drives resistance to anti-BCMA T-cell–redirecting therapy in multiple myeloma

2025-12-11

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor T-cell (CART) and T-cell engager (TCE) therapies targeting B-cell maturation antigen (BCMA) are transforming the treatment landscape for relapsed multiple myeloma (MM). However, despite impressive initial response rates, most patients eventually relapse. To investigate this unmet medical need, we applied whole-genome sequencing (WGS) to MM cells from cohorts of 102 rela...

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Literature Corpus work
25e26cba-9259-5aa2-bb92-804729559b2a
DOI
10.64898/2025.12.08.692978
Open publication

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Plasma cell identity escape drives resistance to anti-BCMA T-cell–redirecting therapy in multiple myelomaDOI 10.64898/2025.12.08.692978
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