Article

Dynamic super-enhancer core regulatory circuits and epigenetic landscapes drive malignant progression and refractory disease in multiple myeloma

2021-01-04

Abstract excerpt

<title>Abstract</title> <p>The plasma cell malignancy multiple myeloma (MM) evolves from a pre-malignant state and remains all but incurable due to emergence of therapy resistance. Despite intensive analyses, mechanisms driving MM progression and refractory disease are poorly understood. Integrating topologic, expression and epigenetic analyses of 1,016 patient specimens, we report super-enhancer core regulatory...

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Literature Corpus work: a1b718e1-9bb8-5315-8892-86b3cb0e0d54
DOI: 10.21203/rs.3.rs-125536/v1

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