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Article

Impact of host cell line adaptation on quasispecies composition and glycosylation of influenza A virus hemagglutinin.

PloS one - 1 Jan 2011

Roedig Jana Verena, Rapp Erdmann, Höper Dirk, Genzel Yvonne, Reichl Udo

Abstract excerpt

The genome of influenza A viruses is constantly changing (genetic drift) resulting in small, gradual changes in viral proteins. Alterations within antibody recognition sites of the viral membrane glycoproteins hemagglutinin (HA) and neuraminidase (NA) result in an antigenetic drift, which requires the seasonal update of human influenza virus vaccines. Generally, virus adaptation is necessary to obtain...

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Identifiers

PMID: 22163276
DOI: 10.1371/journal.pone.0027989
PMCID: PMC3233551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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