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Article

Intrahost HA polymorphisms and culture adaptation shape antigenic profiles of H3N2 influenza viruses.

Journal of virology - 17 Feb 2026

Prasai Kritika, Yang Zunlin, Guan Minhui, Li Tao, Ware Daphne, Hang Jun, Wan Xiu-Feng

Abstract excerpt

Accurate antigenic characterization of influenza viruses is critical for vaccine strain selection but is often confounded by intrahost genetic diversity and culture-induced adaptations. We analyzed 60 A(H3N2)-positive nasopharyngeal specimens collected during the 2017-2018 influenza season to determine how virus propagation in MDCK cells affects viral genetic and antigenic properties. Deep sequencing revealed...

Topics

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Antibodies, Viral
Antigenic Variation
Antigens, Viral
Dogs
Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza A Virus, H3N2 Subtype

Influenza, Human

Madin Darby Canine Kidney Cells

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Identifiers

PMID: 41498543
DOI: 10.1128/jvi.01775-25
PMCID: PMC12831994

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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