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Article

In vivo mutation of pre‐mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation

25 May 2013

Abstract excerpt

Mutated spliceosome components are recurrently being associated with perturbed tissue development and disease pathogenesis. Cephalophŏnus (cph), is a zebrafish mutant carrying an early premature STOP codon in the spliceosome component Prpf8 (pre-mRNA processing factor 8). Cph initially develops normally, but then develops widespread cell death, especially in neurons, and is embryonic lethal. Cph mutants...

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PMID: 23714367
DOI: 10.1016/j.febslet.2013.05.030

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