Article

Identification of novel regulators of human naïve pluripotency by means of a genetic switch utilizing the chimeric receptor G-CSFR:GP130

2025-04-10

Abstract excerpt

This study investigated the molecular mechanisms underpinning the transition from primed to naive pluripotency in human pluripotent stem cells (hPSCs) by utilizing a dual genetic switch combining hormone-dependent STAT3-ER T2 and a chimeric GCSFR:gp130 receptor. Upon activation with tamoxifen and G-CSF, hPSCs demonstrated upregulation of naive markers, and sustained self-renewal independent of LIF. Transcriptomic...

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Literature Corpus work: ab2677a9-0e24-5145-96d7-a90b7b523386
DOI: 10.1101/2025.04.09.647577

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