Article

Stem Cell Divisions, Driver Mutations, and Carcinogenesis in Purebred Dogs

2026-04-17

Abstract excerpt

Most cancers are initiated by mutations that inactivate tumour-suppressor genes or activate oncogenes. Fitting a multistage model of carcinogenesis to the increase in cancer mortality with breed-specific size and lifespan in dogs has predicted that four somatic driver mutations are typically required to initiate cancer. This result is reconsidered here because it depends on the relationship between the number of a...

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Literature Corpus work: 52fc4048-7a37-5bf5-b2e1-46b2fa5eb318
DOI: 10.64898/2026.04.14.718346

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