Article

Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithelial tissues

2026-06-08

Abstract excerpt

Modeling human epithelia in vitro remains challenging because current systems do not fully preserve the combination of architecture, heterogeneity, clonal composition, and long-term dynamics shown in vivo. While 3D approaches such as organoids and organotypic cultures capture important aspects of lineage differentiation and niche signaling, they often lose stable organization over time, limiting studies of long-la...

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Literature Corpus work: 43699e2a-8b76-5bbc-8d9f-fe002718e3cc
DOI: 10.64898/2026.06.07.730560

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