Article

Early origin and deep conservation of enhancers in animals

2019-05-09

Abstract excerpt

Transcription factors (TFs) bind DNA enhancer sequences to regulate gene transcription in animals. Unlike TFs, the evolution of enhancers has been difficult to trace because of their rapid evolution. Here, we show enhancers from the sponge Amphimedon queenslandica can drive cell type-specific reporter gene expression in zebrafish and mouse, despite sponge and vertebrate lineages diverging over 700 million years a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aaea672b-cfd6-5c52-ad85-adbf169b1350
DOI: 10.1101/633651

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early origin and deep conservation of enhancers in animalsDOI 10.1101/633651Read

SEA version 3.0: a comprehensive extension and update of the Super-Enhancer archive.Semantic proximity Read

Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancersSemantic proximity Read

De novo genesis of enhancers in vertebrates.Semantic proximity Read

Architecture and evolutionary conservation of <i>Xenopus tropicalis</i> osteoblast-specific regulatory regions shed light on bone diseases and early skeletal evolutionSemantic proximity Read

Genome-wide analysis of functional and evolutionary features of tele-enhancers.Semantic proximity Read

Functionally conserved enhancers with divergent sequences in distant vertebrates.Semantic proximity Read

Fish-Ing for Enhancers in the Heart.Semantic proximity Read

Exploratory bioinformatics analysis reveals importance of “junk” DNA in early embryo developmentSemantic proximity Read

A systematic approach to identify functional motifs within vertebrate developmental enhancers.Semantic proximity Read

Divergence of CpG island promoters: a consequence or cause of evolution?Semantic proximity Read

Heart enhancers with deeply conserved regulatory activity are established early in developmentSemantic proximity Read

Recent advances in high-throughput approaches to dissect enhancer functionSemantic proximity Read