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Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation.

Stem cell research & therapy - 2 Jan 2024

Hovhannisyan Yeranuhi, Li Zhenlin, Callon Domitille, Suspène Rodolphe, Batoumeni Vivien, Canette Alexis, Blanc Jocelyne, Hocini Hakim, Lefebvre Cécile, El-Jahrani Nora, Kitsara Maria, L'honoré Aurore, Kordeli Ekaterini, Fornes Paul, Concordet Jean-Paul, Tachdjian Gérard, Rodriguez Anne-Marie, Vartanian Jean-Pierre, Béhin Anthony, Wahbi Karim, Joanne Pierre, Agbulut Onnik

Abstract excerpt

BACKGROUND: Beyond the observed alterations in cellular structure and mitochondria, the mechanisms linking rare genetic mutations to the development of heart failure in patients affected by desmin mutations remain unclear due in part, to the lack of relevant human cardiomyocyte models. METHODS: To shed light on the role of mitochondria in these mechanisms, we investigated cardiomyocytes derived from human induced...

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Identifiers

PMID: 38167524
DOI: 10.1186/s13287-023-03619-7
PMCID: PMC10763022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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