Article

Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation

2023-09-18

Abstract excerpt

Beyond the observed alterations in cellular structure and mitochondria, the cellular mechanisms linking genetic mutations to the development of heart failure in patients affected by desmin defects remain unclear due, in part, to the lack of relevant human cardiomyocyte models. We investigated the role of mitochondria using cardiomyocytes derived from human induced pluripotent stem cells carrying the heterozygous...

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Literature Corpus work: f2b7e535-3683-5d93-99f9-73dc7d26fbbc
DOI: 10.1101/2023.09.14.557734

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