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Article

Extracellular microRNA signature in chronic kidney disease.

American journal of physiology. Renal physiology - 1 Jun 2017

Muralidharan Jagdeesan, Ramezani Ali, Hubal Monica, Knoblach Susan, Shrivastav Shashi, Karandish Sara, Scott Richard, Maxwell Nirmal, Ozturk Savas, Beddhu Srinivasan, Kopp Jeffrey B, Raj Dominic S

Abstract excerpt

MicroRNAs (miRNAs) are noncoding RNAs that regulate posttranscriptional gene expression. In this study we characterized the circulating and urinary miRNA pattern associated with reduced glomerular filtration rate, using Affymetrix GeneChip miR 4.0 in 28 patients with chronic kidney disease (CKD). Top miRNA discoveries from the human studies were validated in an Alb/TGFβ mouse model of CKD, and in rat renal...

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Albumins
Fibrosis
Gene Regulatory Networks
Glomerular Filtration Rate
Mice, Inbred CBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Renal Insufficiency, Chronic

Transforming Growth Factor beta

Transforming Growth Factor beta1

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Identifiers

PMID: 28077372
DOI: 10.1152/ajprenal.00569.2016
PMCID: PMC5495885

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