Alzheimer’s Disease: Molecular Mechanisms of the Disease and Involved Factors — A Comprehensive Narrative Review

Abstract excerpt

<h4>Background: </h4> Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. Its hallmarks are extracellular amyloid-beta (Aβ) plaques and intracellular hyperphosphorylated tau forming neurofibrillary tangles, leading to synaptic dysfunction and neuronal loss. Despite extensive research, the mechanisms driving these proteinopathies and the contribution of...

Topics

Open a Topic to create a Post that cites this publication.

• Alzheimer Disease
• Amyloid beta-Peptides
• Amyloid beta-Protein Precursor
• Genome-Wide Association Study
• Mutation
• Neurodegenerative Diseases
• Presenilin-1
• Presenilin-2

Identifiers and source

Literature Corpus work

0f9afc79-94e5-50d5-b93a-264936892cae

DOI

10.20944/preprints202603.0482.v1