Article

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression

2023-02-21

Abstract excerpt

Increased mitochondrial function may render some cancers vulnerable to mitochondrial inhibitors. Since mitochondrial function is regulated partly by mitochondrial DNA copy number (mtDNAcn), accurate measurements of mtDNAcn could help reveal which cancers are driven by increased mitochondrial function and may be candidates for mitochondrial inhibition. However, prior studies have employed bulk macrodissections that...

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Literature Corpus work: aa8ea4a1-2832-53f6-8025-ee360c13e8a1
DOI: 10.1101/2023.02.20.529259

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