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Article

Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression.

Journal of cellular physiology - 1 Jun 2016

Philley Julie V, Kannan Anbarasu, Qin Wenyi, Sauter Edward R, Ikebe Mitsuo, Hertweck Kate L, Troyer Dean A, Semmes Oliver J, Dasgupta Santanu

Abstract excerpt

Mitochondria (mt) encoded respiratory complex-I (RCI) mutations and their pathogenicity remain largely unknown in prostate cancer (PCa). Little is known about the role of mtDNA loss on mt integrity in PCa. We determined mtDNA mutation in human and mice PCa and assessed the impact of mtDNA depletion on mt integrity. We also examined whether the circulating exosomes from PCa patients are transported to mt and carry...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26530043
DOI: 10.1002/jcp.25240
PMCID: PMC5741292

Genes

MFN2
PINK1
IMMT
MFN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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