Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial mutations drive prostate cancer aggression

18 Sept 2017

Abstract excerpt

Nuclear mutations are well known to drive tumor incidence, aggression and response to therapy. By contrast, the frequency and roles of mutations in the maternally inherited mitochondrial genome are poorly understood. Here we sequence the mitochondrial genomes of 384 localized prostate cancer patients, and identify a median of one mitochondrial single-nucleotide variant (mtSNV) per patient. Some of these mtSNVs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Mitochondrial Function and Pathology
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28939825
DOI: 10.1038/s41467-017-00377-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial mutations drive prostate cancer aggressionPMID 28939825Read ↗

Mitochondrial genome variation and prostate cancer: a review of the mutational landscape and application to clinical managementSemantic proximity Read ↗

Mutational load of the mitochondrial genome predicts pathological features and biochemical recurrence in prostate cancer.Semantic proximity Read ↗

Somatic mutations throughout the entire mitochondrial genome are associated with elevated PSA levels in prostate cancer patients.Semantic proximity Read ↗

The mitochondrial and autosomal mutation landscapes of prostate cancer.Semantic proximity Read ↗

The Germline and Somatic Origins of Prostate Cancer Heterogeneity.Semantic proximity Read ↗

Spectrum of mitochondrial genomic variation and associated clinical presentation of prostate cancer in South African men.Semantic proximity Read ↗

Mitochondrial DNA variation and cancer.Semantic proximity Read ↗

Mitochondria, prostate cancer, and biopsy sampling error.Semantic proximity Read ↗

Mitochondrial Alterations in Prostate Cancer: Roles in Pathobiology and Racial DisparitiesSemantic proximity Read ↗

Mitochondrial mutations in early stage prostate cancer and bodily fluids.Semantic proximity Read ↗

Simultaneous generation of multiple mitochondrial DNA mutations in human prostate tumors suggests mitochondrial hyper-mutagenesis.Semantic proximity Read ↗

MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.