Article

RANK is an independent biomarker of poor prognosis in estrogen receptor-negative breast cancer and a therapeutic target in patient-derived xenografts

2021-12-14

Abstract excerpt

Despite strong preclinical data, the therapeutic benefit of the RANKL inhibitor denosumab in BC patients, beyond its bone-related effects, is unclear. Here, we investigated the prognostic value of RANK expression and its functionality in human BC. We analyzed RANK and RANKL expression in more than 1500 BC cases (777 being estrogen receptor-negative (ER - )) from four independent cohorts. We confirmed that RANK is...

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Literature Corpus work: aa82d2b7-560a-51e6-a3fe-45dcb6b8080d
DOI: 10.1101/2021.12.13.470911

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