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Article

Prevention of breast cancer by RANKL/RANK blockade.

Cell research - 1 Jul 2016

Galluzzi Lorenzo, Buqué Aitziber, Kroemer Guido

Abstract excerpt

Robust genetic evidence in mice and humans indicates that RANK signaling plays a major role in mammary carcinogenesis driven by BRCA1/BRCA2 mutations. These findings may inaugurate a new era of breast cancer prevention, changing the life of millions of women worldwide.

Read the complete abstract on PubMed

Topics

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Share to Breast Neoplasms
Share to Cell Transformation, Neoplastic
Share to BRCA1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 gene

Share to Mutation

Share to Receptor Activator of Nuclear Factor-kappa B

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 27325297
DOI: 10.1038/cr.2016.79
PMCID: PMC5129887

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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