Article

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of a-synuclein

2019-12-23

Abstract excerpt

<h4>Summary</h4> Neuropathological and experimental evidence suggests that the cell-to-cell transfer of a-synuclein has an important role in the pathogenesis of Parkinson’s disease (PD). However, the mechanism underlying this phenomenon is not fully understood. We undertook an siRNA, genome-wide high throughput screen to identify genes regulating the cell-to-cell transfer of a-synuclein. We transiently transfecte...

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Literature Corpus work: aa726477-0a86-50cf-8fb7-55f3996cbd0c
DOI: 10.1101/2019.12.23.886838

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