Article

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease

2024-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-synuclein (αSyn) is an intrinsically disordered protein that accumulates in the brains of patients with Parkinson’s disease and forms intraneuronal inclusions called Lewy Bodies. While the mechanism underlying the dysregulation of αSyn in Parkinson’s disease is unclear, it is thought that prionoid cell-to-cell propagation of αSyn has an important role. Through a high throughput screen, we...

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Literature Corpus work: 4c443f23-ef49-5584-8290-17b4053b4df9
DOI: 10.1101/2024.08.30.610195

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